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We found 2 data for " apoptosis"

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NO. DATASET TITLE
1.
POTENTIAL ANGIOPREVENTIVE AGENT OF BENZOQUINONOID COMPUND FROM ARDISIA CRISPA ROOT IN VITRO AND IN VIVO
DESCRIPTION : Ardisia crispa (Thunb) A.DC is a local medicinal plant traditionally claimed for its therapeutic use in various inflammatory-related diseases. Its root part has been scientifically validated to be effective in various inflammatory animal models. In this study, we isolated its bioactive compound (AC2) from the hexane fractionated extract of the plant's root (ACRH) and tested its antiangiogenic properties against human umbilical vein endothelial cells (HUVECs) and zebra fish assay, respectively. Our findings exhibited promising antiangiogenic effects of both AC2 and ACRH by suppressing its angiogenic signaling cascades, in vitro as well as significantly inhibited zebrafish embryo intersegmental vessels (ISVs), confirming its antiangiogenic role
CONTRIBUTOR : ROSLIDA BINTI ABD HAMID @ ABDUL RAZAK (29/12/2023 12:18 PM)
FACULTY : FAKULTI PERUBATAN DAN SAINS KESIHATAN
PUBLICATION : 1 ; FILE IN :
HAS VIEWS : 18 ; FOLDER IN PROJECT : 0 ; FILE IN PROJECT : 0 ; DOWNLOAD : 0 ;
KEYWORD : [Ardisia crispa] , [ 2-methoxy-6-undecyl-1] , [4-benzoquinone. HUVECs] , [ cell migration] , [ cell invasion] , [ tube formation] , [ VEGF]
2.
COMBINATION OF VP3 AND CD147-KNOCKDOWN ENHANCE APOPTOSIS AND TUMOR GROWTH DELAY INDEX IN COLORECTAL TUMOR ALLOGRAFT
DESCRIPTION : Cancer therapies that kill cancer cells without affecting normal cells is the ultimate mode of treating cancers. The VP3, an avian virus-derived protein, can specifically initiate cell death through several signal transduction pathways leading to apoptosis. In cancer, chemoresistance and cell survivability implicate the cell surface protein, CD147. Methods In this study, transfection of VP3 and silencing of CD147 genes was achieved through the treatment of tumors with pVIVO1-GFP/VP3 (VP3), psiRNA-CD147/2 (shCD147/2), and their combination of CT26 colon cancer cell-induced in mice. The effectiveness of tumor-treatment was ascertained by electrophoresis, TUNEL assay, and flow cytometry analysis. While histopathological and biochemical analysis were used as toxic side effect identification. Results The tumor growth delay index (TGDI) after treatment with VP3, shCD147/2, and their combination treatments increased by 1.3-, 1.2-, 2.0- and 2.3-fold respectively, over untreated control. The VP3-shCD147/2 combination treatment was more efficacious then either VP3 or shCD147/2 alone in the retardation of mouse CT26 colorectal cell tumor allograft. Conclusion The antitumor effect of the combination treatment is the result of synergistic effects of VP3 and shCD147/2 on the tumor cells resulting in apoptosis. Thus, the study shows that combination of VP3 and shCD147/2 treatment can be developed into a potential approach for anticolorectal cancer treatment regimen.
CONTRIBUTOR : MOHD AZMI BIN MOHD LILA (11/05/2023 15:35 PM)
FACULTY : FAKULTI PERUBATAN VETERINAR
PUBLICATION : 0 ; FILE IN : HDFS 
HAS VIEWS : 625 ; FOLDER IN PROJECT : 1 ; FILE IN PROJECT : 1 ; DOWNLOAD : 1 ;
KEYWORD : [pVIVO1-GFP/VP3] , [ psiRNA-CD147/2] , [ CT26 colon cancer cell tumor] , [ Apoptosis]

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Fakulti Perubatan Dan Sains Kesihatan [25]
Fakulti Sains [18]
Fakulti Bioteknologi Dan Sains Biomolekul [6]
Fakulti Sains Komputer Dan Teknologi Maklumat [1]
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Institut Pertanian Tropika Dan Sekuriti Makanan [1]
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Fakulti Sains Dan Teknologi Makanan [1]
Pusat Pembangunan Maklumat Dan Komunikasi [1]
Fakulti Ekonomi Dan Pengurusan [2]
Fakulti Perubatan Veterinar [4]
Fakulti Pertanian [8]
Fakulti Ekologi Manusia [2]
Institut Penyelidikan Produk Halal [1]
Institut Penyelidikan Matematik [1]
Fakulti Sains Pertanian Dan Makanan [2]
Institut Perhutanan Tropika Dan Produk Hutan [2]
Kampus Upm Bintulu [1]
Fakulti Perhutanan [6]

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