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We found 3 data for " diabetes mellitus"

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NO. DATASET TITLE
1.
URINARY METABOLOMICS STUDY ON THE PROTECTIVE ROLE OF ORTHOSIPHON STAMINEUS IN STREPTOZOTOCIN INDUCED DIABETES MELLITUS IN RATS VIA 1H NMR SPECTROSCOPY
DESCRIPTION : Orthosiphon stamineus (OS) is a herb known in ethnomedicine for treating diabetes mellitus (DM). In this study, a 1H NMR based urine metabolomics tool has been used for the first time to identify the metabolic protective mechanism of OS in DM using Streptozotocin (STZ) induced experimental model in rats. Methods Four different solvent extracts of OS, namely aqueous, ethanolic, 50% aqueous ethanolic and methanolic, at a dose of 500Â mg/kg body weight (bw) were orally administered for 14 days to diabetic rats induced via intraperitoneal injection of 60Â mg/kg bw STZ. NMR metabolomics approach using pattern recognition combined with multivariate statistical analysis was applied in the rat urine to study the resulted metabolic perturbations. Results OS aqueous extract (OSAE) caused a reversal of DM comparable to that of 10Â mg/kg bw glibenclamide. A total of 15 urinary metabolites, which levels changed significantly upon treatment were identified as the biomarkers of OSAE in diabetes. A systematic metabolic pathways analysis identified that OSAE contributed to the antidiabetic activity mainly through regulating the tricarboxylic acid cycle, glycolysis/gluconeogenesis, lipid and amino acid metabolism. Conclusions The results of this study validated the ethnopharmacological use of OS in diabetes and unveiled the biochemical and metabolic mechanisms involved.
CONTRIBUTOR : AMIN BIN ISMAIL (12/05/2023 16:21 PM)
FACULTY : FAKULTI PERUBATAN DAN SAINS KESIHATAN
PUBLICATION : 0 ; FILE IN : HDFS 
HAS VIEWS : 2036 ; FOLDER IN PROJECT : 1 ; FILE IN PROJECT : 1 ; DOWNLOAD : 2 ;
KEYWORD : [Orthosiphon Stamineus] , [ Java tea] , [ Metabolomics] , [ Diabetes mellitus] , [ 1H NMR spectroscopy]
2.
EMOTIONAL BURDEN AND ITS EFFECT ON DISEASE CONTROL, MEDICATION ADHERENCE AND QUALITY OF LIFE IN PATIENTS WITH TYPE 2 DIABETES MELLITUS
DESCRIPTION : Purpose: This study examined the association between medication adherence (MA) and health-related quality of life (HRQoL) among the adult type 2 diabetes mellitus at the primary care level. Methods: In this cross-sectional study, the 8-item Morisky Medication Adherence Scale (MMAS) was the main independent variable and the World Health Organization Quality of Life-Brief the dependent variable. Besides socio-demographic data, diabetes-related distress (DRD) and depression (DS) were included as covariates. Independent association between the MMAS score and HRQoL was done using multiple linear regression.
CONTRIBUTOR : CHEW BOON HOW (11/05/2023 16:42 PM)
FACULTY : FAKULTI PERUBATAN DAN SAINS KESIHATAN
PUBLICATION : 0 ; FILE IN : HDFS 
HAS VIEWS : 1696 ; FOLDER IN PROJECT : 1 ; FILE IN PROJECT : 1 ; DOWNLOAD : 0 ;
KEYWORD : [Medication adherence; Primary care; Quality of life; Type 2 diabetes mellitus.]
3.
THE MALAYSIAN GESTATIONAL DIABETES AND PREVENTION OF DIABTES STUDY (MY GODDESS)
DESCRIPTION : Over 50% of women with a history of gestational diabetes mellitus (GDM) will develop type 2 diabetes (T2D) in later life. Asian women experience a disproportionate risk of both GDM and T2D compared to women from other ethnic backgrounds. Lifestyle interventions and behavior change can delay or even prevent the onset of T2D. We have developed a digitalized diabetes prevention intervention for the prevention of T2D in Malaysian women with GDM.
CONTRIBUTOR : CHEW BOON HOW (11/05/2023 16:18 PM)
FACULTY : FAKULTI PERUBATAN DAN SAINS KESIHATAN
PUBLICATION : 2 ; FILE IN :
HAS VIEWS : 1301 ; FOLDER IN PROJECT : 0 ; FILE IN PROJECT : 0 ; DOWNLOAD : 0 ;
KEYWORD : [gestational diabetes mellitus] , [ diabetes prevention] , [ randomized controlled trial] , [ mobile app]

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