DATASETS MEDICINE

We found 29 data for "MEDICINE"

LIST DATASET

NO. DATASET TITLE
1.
CHANGES IN ANTHROPOMETRIC, BODY COMPOSITION, CLINICAL PARAMETERS, BIOCHEMICAL PROFILES, AND BIOMARKERS CONCENTRATION OF SUBCLINICAL ATHEROSCLEROSIS OF THE EBN INTERVENTION AMONG PREMENOPAUSAL WOMEN: A RANDOMIZED CONTROL TRIAL
DESCRIPTION : Introduction: The menopausal transition is an important physiological stage in the lives of women that is associated with the risk of cardiovascular disease later in life. Objective: This study aimed to describe changes in anthropometric measurements, body composition, clinical parameters, biochemical profiles, biomarker concentration, and carotid ultrasound to address risk factors for subclinical atherosclerosis disease among premenopausal women with borderline hypercholesterolemia before and after intervention. This was a 12-week randomized control trial comparing an intervention with an edible bird nest with a control. Subjects: The study involved 39 premenopausal women 40-55 years of age who, following inclusion and exclusion criteria, were allocated into two groups, an intervention group consuming one (1) pouch (250 g) of edible bird nest mix (EBN) daily for 12 weeks (between days 84 and 90 days from day 1 of menses) and the control group consuming the same weight, texture and taste of the placebo. Main outcome measures: Assessment before and after inclusion of the anthropometric status parameters [weight, height, body mass index, hip, waist to hip ratio (WHR), body composition (body fat, body age, whole body skeletal, trunk skeletal, arm skeletal, leg skeletal, total body subcutaneous, trunk subcutaneous, arm subcutaneous, leg subcutaneous, visceral fat), clinical parameters (blood pressure (systolic and diastolic), thickness of the carotid intima, biochemical profiles (lipid profile, lasting blood glucose), biomarker concentrations (APO AI, APO AII, APO B, APO CII, APO CIII, APO E). This study showed that the EBN intervention for premenopausal women with mild hypercholesterolemia resulted in slightly beneficial changes in anthropometric measurement, body composition, clinical parameters, and biomarker concentration associated with cardiovascular risk in older women. These findings present a potential for the use of EBN in individuals with borderline hypercholesterolemia to provide cholesterol lowering benefit based on an animal-based diet strategy that can improve overall health outcomes when reaching menopausal age.
CONTRIBUTOR : SALWANA BINTI AHMAD (25/12/2023 16:43 PM)
FACULTY : INSTITUT BIOSAINS
PUBLICATION : 0 ; FILE IN : HDFS 
HAS VIEWS : 17 ; FOLDER IN PROJECT : 1 ; FILE IN PROJECT : 1 ; DOWNLOAD : 1 ;
KEYWORD : [Biochemical profile] , [ subclinical atherosclerosis] , [ carotid intima media thickness] , [ ovary size] , [ vascular aging] , [ premenopausal women.]
2.
EFFECT OF MICROBIAL CELL PREPARATION ON RENAL PROFILE AND LIVER FUNCTION AMONG TYPE 2 DIABETICS: A RANDOMIZED CONTROLLED TRIAL
DESCRIPTION : The beneficial effect of probiotics on renal profile and liver function has been reported among patients with chronic kidney disease and fatty liver respectively. However, its effect on renal profile and liver function among type 2 diabetic individuals has not been fully understood. To investigate the effect of microbial cell preparation on renal profile and liver function tests among type 2 diabetic individuals. Methods A randomized, double-blind, parallel-group, controlled clinical trial was conducted on a total of 136 type 2 diabetics age 30-70 years old in a teaching hospital in Kuala Lumpur, Malaysia. Subjects were randomly assigned to receive microbial cell preparation (N = 68) or a placebo (N = 68) for 12 weeks. The outcomes measured at baseline, week 6, and week 12 and included changes in renal profile (Sodium, Potassium, Urea, Creatinine, Glomerular Filtration Rate), and liver function tests (Albumin, Total Protein, Alkaline Phosphatase, Alanine Aminotransferase, Aspartate Aminotransferase). Intention to treat (ITT) analysis was performed on all the recruited subjects, while per protocol (PP) analysis was conducted on those who completed the trial with good compliance. Result The urea levels significantly declined in the probiotic group. Serum urea levels reduced from 4.26 mmol/L to 4.04 mmol/L in Probiotic Group while it increased in Placebo Group from 4.03 mmol/L to 4.24 mmol/L. These changes were significant between groups in ITT analysis (p = 0.018). Other parameters did not change significantly between groups. Conclusion 12 weeks supplementation with daily dosage of 6 × 1010 Colony Forming Units of multi-strain microbial cell preparation significantly improved urea levels.
CONTRIBUTOR : AMIN BIN ISMAIL (12/05/2023 16:37 PM)
FACULTY : FAKULTI PERUBATAN DAN SAINS KESIHATAN
PUBLICATION : 0 ; FILE IN : HDFS 
HAS VIEWS : 2108 ; FOLDER IN PROJECT : 1 ; FILE IN PROJECT : 3 ; DOWNLOAD : 22 ;
KEYWORD : [Microbial cell preparation] , [ Probiotics] , [ Urea] , [ Renal profile] , [ Liver function tests] , [ Type 2 diabetes] , [ Lactobacillus] , [ Bifidobacterium]
3.
EFFECT OF DIFFERENT DRYING TREATMENTS AND SOLVENT RATIOS ON PHYTOCHEMICAL CONSTITUENTS OF IPOMOEA AQUATICA AND CORRELATION WITH α-GLUCOSIDASE INHIBITORY ACTIVITY
DESCRIPTION : Ipomoea aquatica is an aquatic plant that is widely consumed in Southeast Asia as a vegetable. In this study, the influence of various ethanol ratios (0, 20, 50, 80, and 100%) as an extraction solvent and different drying methods including air drying (AD), sun drying (SD) and oven drying (OD) on phytochemical constituents of I. aquatica was investigated using a proton nuclear magnetic resonance (1H NMR) based metabolomics approach. The effect on α-glucosidase inhibitory activity and total phenolic content (TPC) was also examined. Clear discrimination was observed between different ethanol ratios and different drying processes by principal component analysis (PCA). The highest α-glucosidase inhibitory activity was observed for absolute ethanol extract from the OD method with IC50 value of 204.0 ± 59.0 µg/mL and TPC value of 22.0 ± 0.7 µg GAE/mg extract. Correlation between the α-glucosidase inhibitory activity and the metabolite were analyzed using a partial least square (PLS) analysis. The metabolites that are responsible for the activity were quercetin derivatives, chlorogenic acid derivatives, sucrose and fructose. This study highlights the basis for future investigations of I. aquatica as a source of food that has the potential for nutraceutical enhancement and as ingredient in medicinal preparation.
CONTRIBUTOR : AMIN BIN ISMAIL (12/05/2023 16:31 PM)
FACULTY : FAKULTI PERUBATAN DAN SAINS KESIHATAN
PUBLICATION : 0 ; FILE IN : HDFS 
HAS VIEWS : 3674 ; FOLDER IN PROJECT : 1 ; FILE IN PROJECT : 1 ; DOWNLOAD : 6 ;
KEYWORD : [1H NMR metabolomics] , [ Ipomoea aquatica] , [ Alpha-glucosidase inhibitory] , [ PLS]
4.
URINARY METABOLOMICS STUDY ON THE PROTECTIVE ROLE OF ORTHOSIPHON STAMINEUS IN STREPTOZOTOCIN INDUCED DIABETES MELLITUS IN RATS VIA 1H NMR SPECTROSCOPY
DESCRIPTION : Orthosiphon stamineus (OS) is a herb known in ethnomedicine for treating diabetes mellitus (DM). In this study, a 1H NMR based urine metabolomics tool has been used for the first time to identify the metabolic protective mechanism of OS in DM using Streptozotocin (STZ) induced experimental model in rats. Methods Four different solvent extracts of OS, namely aqueous, ethanolic, 50% aqueous ethanolic and methanolic, at a dose of 500Â mg/kg body weight (bw) were orally administered for 14 days to diabetic rats induced via intraperitoneal injection of 60Â mg/kg bw STZ. NMR metabolomics approach using pattern recognition combined with multivariate statistical analysis was applied in the rat urine to study the resulted metabolic perturbations. Results OS aqueous extract (OSAE) caused a reversal of DM comparable to that of 10Â mg/kg bw glibenclamide. A total of 15 urinary metabolites, which levels changed significantly upon treatment were identified as the biomarkers of OSAE in diabetes. A systematic metabolic pathways analysis identified that OSAE contributed to the antidiabetic activity mainly through regulating the tricarboxylic acid cycle, glycolysis/gluconeogenesis, lipid and amino acid metabolism. Conclusions The results of this study validated the ethnopharmacological use of OS in diabetes and unveiled the biochemical and metabolic mechanisms involved.
CONTRIBUTOR : AMIN BIN ISMAIL (12/05/2023 16:21 PM)
FACULTY : FAKULTI PERUBATAN DAN SAINS KESIHATAN
PUBLICATION : 0 ; FILE IN : HDFS 
HAS VIEWS : 2029 ; FOLDER IN PROJECT : 1 ; FILE IN PROJECT : 1 ; DOWNLOAD : 2 ;
KEYWORD : [Orthosiphon Stamineus] , [ Java tea] , [ Metabolomics] , [ Diabetes mellitus] , [ 1H NMR spectroscopy]
5.
VALIDATION AND RELIABILITY OF KNOWLEDGE, ATTITUDE, AND PRACTICE OF CORONAVIRUS DISEASE 2019 QUESTIONNAIRE
DESCRIPTION : To controlling the spread of coronavirus disease 2019 (COVID-19) and decreasing the infection rate is adherence to preventive measures.
CONTRIBUTOR : LIM POH YING (12/05/2023 10:26 AM)
FACULTY : FAKULTI PERUBATAN DAN SAINS KESIHATAN
PUBLICATION : 0 ; FILE IN : HDFS 
HAS VIEWS : 1154 ; FOLDER IN PROJECT : 1 ; FILE IN PROJECT : 1 ; DOWNLOAD : 0 ;
KEYWORD : [COVID-19; knowledge; practice]
6.
IN-VIVO STUDY OF SYNTHETIC AND NATURAL FOOD COLORS EFFECT ON BIOCHEMICAL AND IMMUNITY PARAMETERS
DESCRIPTION : Incorporation of the coloring agent, tartrazine and curcumin affects healthy physiological system leading to changes in hematology, biochemistry and enzymatic activity. Consequences of oral administration of tartrazine and curcumin were explored for 15, 30 and 45 days in female adult rat. Two doses were based on the admissible daily intake (ADI) of 9.6 and 96 (high) mg/kg/body weight for tartrazine, 3.85 and 38.5 mg/kg/body weight for curcumin. Phytochemicals such as saponins, glycosides, alkaloids, flavonoids, tannin, carbohydrates and phenolics were present in coloring agents. The renal function tests and lipid profile showed alterations in the values of uric acid, urea, total protein, albumin and cholesterol in all treatment groups. Additionally, the levels of liver enzymes fluctuated after 45 days of treatment with curcumin and tartrazine. Histopathological changes were also recorded in liver and kidney. In contrast, blood biochemistry depicted the significant reduction of RBCs, Hb, MCH, glucose, WBCs, MCHC and LDH at 15, 30 and 45 days. Besides, IgG, IgM and overall antibody GMT at 45 days were significantly increased. Study indicated that ADI and doses up to 10 times of the ADI of food colors intake exerted adverse effects on immune response and altered the biochemical parameters.
CONTRIBUTOR : AMIN BIN ISMAIL (12/05/2023 10:15 AM)
FACULTY : FAKULTI PERUBATAN DAN SAINS KESIHATAN
PUBLICATION : 0 ; FILE IN : HDFS 
HAS VIEWS : 1352 ; FOLDER IN PROJECT : 1 ; FILE IN PROJECT : 1 ; DOWNLOAD : 0 ;
KEYWORD : [food colors; hematology; antibody; toxicology; biochemistry; immunity]
7.
DATASET, MODULE AND QUESTIONNAIRE OF TEACHERS' BELIEFS ABOUT DRUG ABUSE
DESCRIPTION : This study assessed the effect of electronic module of learning material about drugs and the prevention toward teachers' beliefs in preventing drug abuse. The database including variable dataset, module and questionnaire of teachers' beliefs about drug abuse and the prevention.
CONTRIBUTOR : NOR AFIAH BINTI MOHD ZULKEFLI (12/05/2023 09:53 AM)
FACULTY : FAKULTI PERUBATAN DAN SAINS KESIHATAN
PUBLICATION : 0 ; FILE IN : HDFS 
HAS VIEWS : 1464 ; FOLDER IN PROJECT : 1 ; FILE IN PROJECT : 1 ; DOWNLOAD : 0 ;
KEYWORD : [drug abuse] , [ electronic module] , [ teachers beliefs]
8.
ASSOCIATION OF SOIL FUNGAL COMMUNITY COMPOSITION WITH INCIDENCE OF FUSARIUM WILT OF BANANA IN MALAYSIA
DESCRIPTION : Banana (Musa spp.), an important food crop in many parts of the world, is threatened by a deadly wilt disease caused by Fusarium oxysporum f. sp. cubense Tropical Race 4 (TR4). Increasing evidence indicates that plant actively recruits beneficial microbes in the rhizosphere to suppress soil-borne pathogens. Hence, studies on the composition and diversity of the root-associated microbial communities are important for banana health. Research on beneficial microbial communities has focused on bacteria, although fungi can also influence soil-borne disease. Here, high-throughput sequencing targeting the fungal internal transcribed spacer (ITS) was employed to systematically characterize the difference in the soil fungal community associated with Fusarium wilt (FW) of banana. The community structure of fungi in the healthy and TR4-infected rhizospheres was significantly different compared with that of bulk soil within the same farm. The rhizosphere soils of infected plants exhibited higher richness and diversity compared with healthy plants, with significant abundance of Fusarium genus at 14%. In the healthy rhizosphere soil, Penicillium spp. were more abundant at 7% and positively correlated with magnesium. This study produced a detailed description of fungal community structure in healthy and TR4-infected banana soils in Malaysia and identified candidate biomarker taxa that may be associated with FW disease promotion and suppression. The findings also expand the global inventory of fungal communities associated with the components of asymptomatic and symptomatic banana plants infected by TR4.
CONTRIBUTOR : NOORADIBAH BINTI ISMAIL (11/05/2023 19:35 PM)
FACULTY : FAKULTI BIOTEKNOLOGI DAN SAINS BIOMOLEKUL
PUBLICATION : 0 ; FILE IN : HDFS 
HAS VIEWS : 4706 ; FOLDER IN PROJECT : 1 ; FILE IN PROJECT : 1 ; DOWNLOAD : 6 ;
KEYWORD : [internal transcribed spacer] , [ rhizosphere] , [ richness] , [ soil microbiome] , [ soil physicochemical properties] , [ TR4]
9.
WILLINGNESS TO PAY FOR HEPATITIS B VACCINATION IN SELANGOR, MALAYSIA: A CROSS-SECTIONAL HOUSEHOLD SURVEY
DESCRIPTION : Raw data for manuscript: Willingness to Pay for Hepatitis B Vaccination in Selangor, Malaysia: A Cross-Sectional Household Survey. This manuscript is submitted to Plos ONE.
CONTRIBUTOR : NIAZLIN BINTI MOHD TAIB (11/05/2023 19:22 PM)
FACULTY : FAKULTI PERUBATAN DAN SAINS KESIHATAN
PUBLICATION : 0 ; FILE IN : HDFS 
HAS VIEWS : 1885 ; FOLDER IN PROJECT : 1 ; FILE IN PROJECT : 1 ; DOWNLOAD : 11 ;
KEYWORD : [Hepatitis B] , [ vaccine] , [ malaysia] , [] , [ survey]
10.
IN DEPTH ANALYSIS OF THE SOX4 GENE LOCUS THAT CONSISTS OF SENSE AND NATURAL ANTISENSE TRANSCRIPTS
DESCRIPTION : SRY (Sex Determining Region Y)-Box 4 or Sox4 is an important regulator of the pan-neuronal gene expression during post-mitotic cell differentiation within the mammalian brain. Sox4 gene locus has been previously characterized with multiple sense and overlapping natural antisense transcripts [1], [2]. Here we provide accompanying data on various analyses performed and described in Ling et al. [2]. The data include a detail description of various features found at Sox4 gene locus, additional experimental data derived from RNA-Fluorescence in situ Hybridization (RNA-FISH), Western blotting, strand-specific reverse-transcription quantitative polymerase chain reaction (RT-qPCR), gain-of-function and in situ hybridization (ISH) experiments. All the additional data provided here support the existence of an endogenous small interfering- or PIWI interacting-like small RNA known as Sox4_sir3, which origin was found within the overlapping region consisting of a sense and a natural antisense transcript known as Sox4ot1.
CONTRIBUTOR : LING KING HWA (11/05/2023 17:05 PM)
FACULTY : FAKULTI PERUBATAN DAN SAINS KESIHATAN
PUBLICATION : 0 ; FILE IN : HDFS 
HAS VIEWS : 2563 ; FOLDER IN PROJECT : 1 ; FILE IN PROJECT : 1 ; DOWNLOAD : 2 ;
KEYWORD : [Endogenous siRNA Brain development Natural antisense transcripts]
11.
EMOTIONAL BURDEN AND ITS EFFECT ON DISEASE CONTROL, MEDICATION ADHERENCE AND QUALITY OF LIFE IN PATIENTS WITH TYPE 2 DIABETES MELLITUS
DESCRIPTION : Purpose: This study examined the association between medication adherence (MA) and health-related quality of life (HRQoL) among the adult type 2 diabetes mellitus at the primary care level. Methods: In this cross-sectional study, the 8-item Morisky Medication Adherence Scale (MMAS) was the main independent variable and the World Health Organization Quality of Life-Brief the dependent variable. Besides socio-demographic data, diabetes-related distress (DRD) and depression (DS) were included as covariates. Independent association between the MMAS score and HRQoL was done using multiple linear regression.
CONTRIBUTOR : CHEW BOON HOW (11/05/2023 16:42 PM)
FACULTY : FAKULTI PERUBATAN DAN SAINS KESIHATAN
PUBLICATION : 0 ; FILE IN : HDFS 
HAS VIEWS : 1685 ; FOLDER IN PROJECT : 1 ; FILE IN PROJECT : 1 ; DOWNLOAD : 0 ;
KEYWORD : [Medication adherence; Primary care; Quality of life; Type 2 diabetes mellitus.]
12.
PERCEPTION OF MALAYSIAN HEALTHCARE PROFESSIONAL TOWARDS FAMILY MEDICINE SPECIALISTS
DESCRIPTION : Perception of healthcare providers who worked with family medicine specialists (FMSs) could translate into the effectiveness of primary healthcare delivery in daily practices. This study examined perceptions of public healthcare providers/professionals (PHCPs) on FMSs at public health clinics throughout Malaysia. This was a cross-sectional study in 2012-2013 using postal method targeting PHCPs from three categories of health facilities, namely health clinics, health offices and hospitals. A structured questionnaire was developed to assess PHCP's perception of FMS's clinical competency, safety practice, ethical and professional values, and research involvement. It consists of 37 items with Likert scale of strongly disagree (a score of 1) to strongly agree (a score of 5). Interaction and independent effect of the independent variables were tested and adjusted means score were reported. The participants' response rate was 58.0% (780/1345) with almost equal proportion from each of the three public healthcare facilities. There were more positive perceptions than negative among the PHCPs. FMSs were perceived to provide effective and safe treatment to their patients equally disregards of patient's social background. However, there were some concerns of FMSs not doing home visits, not seeing walk-in patients, had long appointment time, not active in scientific research, writing and publication. There were significant differences in perception based on a respondent's health care facility (p < 0.0001) and frequency of encounter (p < 0.0001). PHCPs had overall positive perceptions on FMSs across all the domains investigated. PHCPs from different health care facilities and frequency of encounter with FMSs had different perception. Practicing FMSs could improve on the critical service areas that were perceived to be important but lacking. FMSs might need further support in conducting research and writing for publication.
CONTRIBUTOR : CHEW BOON HOW (11/05/2023 16:40 PM)
FACULTY : FAKULTI PERUBATAN DAN SAINS KESIHATAN
PUBLICATION : 0 ; FILE IN : HDFS 
HAS VIEWS : 1009 ; FOLDER IN PROJECT : 1 ; FILE IN PROJECT : 1 ; DOWNLOAD : 0 ;
KEYWORD : [Clinical competence; Clinical ethics; Family physicians; Healthcare providers; Malaysia; Perception; Physician’s practice patterns; Professional competence; Research activities.]
13.
GENOMIC DATA OF LEPTOSPIRA INTERROGANS HP358 ISOLATED FROM RODENT CAPTURED FROM THE HUMAN LEPTOSPIROSIS SUSPECTED AREAS OF SELANGOR STATE, MALAYSIA
DESCRIPTION : The data provided in this article is the genomic sequence of new Leptospira isolate, Leptospira interrogans strain HP358 (L. interrogans HP358) isolated from rodent, Sundamys muelleri (S. muelleri), captured from the human leptospirosis suspected area, in forest environment, Hulu Perdik, Selangor. The kidney of the rodent was cultured, and the genomic DNA of pure Leptospira isolate was extracted and sequenced. The de novo assembly of genome generated 118 contigs with N50 of 133,176bp. The genome size of the L. interrogans HP358 was determined with a length of 4,808,724 and 35.01% G+C content with 229 subsystems, 5236 coding sequences and 39 RNAs. The whole genome shotgun project has been deposited in NCBI GenBank under the accession number JAFCYY000000000.1.
CONTRIBUTOR : VASANTHA KUMARI NEELA (11/05/2023 16:35 PM)
FACULTY : FAKULTI PERUBATAN DAN SAINS KESIHATAN
PUBLICATION : 0 ; FILE IN : HDFS 
HAS VIEWS : 1151 ; FOLDER IN PROJECT : 1 ; FILE IN PROJECT : 0 ; DOWNLOAD : 0 ;
KEYWORD : [Leptospira interrogans] , [ Whole genome sequencing] , [ Rodents] , [ Leptospirosis]
14.
THE MALAYSIAN GESTATIONAL DIABETES AND PREVENTION OF DIABTES STUDY (MY GODDESS)
DESCRIPTION : Over 50% of women with a history of gestational diabetes mellitus (GDM) will develop type 2 diabetes (T2D) in later life. Asian women experience a disproportionate risk of both GDM and T2D compared to women from other ethnic backgrounds. Lifestyle interventions and behavior change can delay or even prevent the onset of T2D. We have developed a digitalized diabetes prevention intervention for the prevention of T2D in Malaysian women with GDM.
CONTRIBUTOR : CHEW BOON HOW (11/05/2023 16:18 PM)
FACULTY : FAKULTI PERUBATAN DAN SAINS KESIHATAN
PUBLICATION : 2 ; FILE IN :
HAS VIEWS : 1291 ; FOLDER IN PROJECT : 0 ; FILE IN PROJECT : 0 ; DOWNLOAD : 0 ;
KEYWORD : [gestational diabetes mellitus] , [ diabetes prevention] , [ randomized controlled trial] , [ mobile app]
15.
COMBINATION OF VP3 AND CD147-KNOCKDOWN ENHANCE APOPTOSIS AND TUMOR GROWTH DELAY INDEX IN COLORECTAL TUMOR ALLOGRAFT
DESCRIPTION : Cancer therapies that kill cancer cells without affecting normal cells is the ultimate mode of treating cancers. The VP3, an avian virus-derived protein, can specifically initiate cell death through several signal transduction pathways leading to apoptosis. In cancer, chemoresistance and cell survivability implicate the cell surface protein, CD147. Methods In this study, transfection of VP3 and silencing of CD147 genes was achieved through the treatment of tumors with pVIVO1-GFP/VP3 (VP3), psiRNA-CD147/2 (shCD147/2), and their combination of CT26 colon cancer cell-induced in mice. The effectiveness of tumor-treatment was ascertained by electrophoresis, TUNEL assay, and flow cytometry analysis. While histopathological and biochemical analysis were used as toxic side effect identification. Results The tumor growth delay index (TGDI) after treatment with VP3, shCD147/2, and their combination treatments increased by 1.3-, 1.2-, 2.0- and 2.3-fold respectively, over untreated control. The VP3-shCD147/2 combination treatment was more efficacious then either VP3 or shCD147/2 alone in the retardation of mouse CT26 colorectal cell tumor allograft. Conclusion The antitumor effect of the combination treatment is the result of synergistic effects of VP3 and shCD147/2 on the tumor cells resulting in apoptosis. Thus, the study shows that combination of VP3 and shCD147/2 treatment can be developed into a potential approach for anticolorectal cancer treatment regimen.
CONTRIBUTOR : MOHD AZMI BIN MOHD LILA (11/05/2023 15:35 PM)
FACULTY : FAKULTI PERUBATAN VETERINAR
PUBLICATION : 0 ; FILE IN : HDFS 
HAS VIEWS : 616 ; FOLDER IN PROJECT : 1 ; FILE IN PROJECT : 1 ; DOWNLOAD : 1 ;
KEYWORD : [pVIVO1-GFP/VP3] , [ psiRNA-CD147/2] , [ CT26 colon cancer cell tumor] , [ Apoptosis]
16.
A SYSTEMATIC REVIEW OF THE EPIDEMIOLOGY OF HEPATITIS E VIRUS INFECTION IN SOUTH – EASTERN ASIA
DESCRIPTION : Hepatitis E virus (HEV) infection is an emerging zoonotic viral disease, with an increasingly international public health challenge. Despite the concerns that the global disease burden may be underestimated. Therefore, evaluation of the disease epidemiology in South – eastern Asia through a systematic review will assist in unraveling the burden of the disease in the subregion. A priori protocol was prepared for the systematic review and followed by a literature search involving five electronic databases. Identified publications were screened for high quality studies and the elimination of bias and relevant data extracted. A total of 4157 citations were captured, and only 35 were included in the review. A wide range of HEV seroprevalence was recorded from 2% (urban blood donors in Malaysia) to 77.7% (lowland communities in Lao PDR). Sporadic HEV infection and epidemics were also detected in the subregion. Indicating hyperendemicity of the disease in South – eastern Asia
CONTRIBUTOR : ZAMBERI BIN SEKAWI (11/05/2023 15:32 PM)
FACULTY : FAKULTI PERUBATAN DAN SAINS KESIHATAN
PUBLICATION : 0 ; FILE IN : HDFS 
HAS VIEWS : 534 ; FOLDER IN PROJECT : 1 ; FILE IN PROJECT : 1 ; DOWNLOAD : 0 ;
KEYWORD : [Hepatitis E] , [ Hepatitis E virus] , [ seroprevalence] , [ sporadic HEV infection] , [ HEV outbreaks] , [ south-eastern asia]
17.
GENE EXPRESSION ANALYSIS REVEALS THE CONCURRENT ACTIVATION OF PRO-APOPTOTIC AND ANTIOXIDANT-DEFENSIVE MECHANISMS IN FLAVOKAWAIN B AND FIH-TREATED CERVICAL CANCER HELA CELLS
DESCRIPTION : To examine the difference in gene expression of HeLa cells after 48 hours of treatment with 7 µg/mL FKB and 15 µg/mL FIH after 48 hours. 3 sets of sample were prepared; the untreated HeLa cells, 7 µg/mL FKB-treated HeLa cells after 48 hours, 15 µg/mL of FIH-treated HeLa cells after 48 hours
CONTRIBUTOR : NOORJAHAN BANU BINTI MOHAMMED ALITHEEN (11/05/2023 14:58 PM)
FACULTY : FAKULTI BIOTEKNOLOGI DAN SAINS BIOMOLEKUL
PUBLICATION : 0 ; FILE IN : HDFS 
HAS VIEWS : 2555 ; FOLDER IN PROJECT : 1 ; FILE IN PROJECT : 4 ; DOWNLOAD : 0 ;
KEYWORD : [HeLa cells] , [ cervical cancer]
18.
REGULATED GENE EXPRESSION FOR BREAST CANCER CELLS TREATED WITH NLC-CITRAL FOR 48 HOURS
DESCRIPTION : To further develop our gene expression study, we have employed the microrarray expression to study the regulate gene expression on breast cancer cells after 48 hours of treatments
CONTRIBUTOR : NOORJAHAN BANU BINTI MOHAMMED ALITHEEN (11/05/2023 14:48 PM)
FACULTY : FAKULTI BIOTEKNOLOGI DAN SAINS BIOMOLEKUL
PUBLICATION : 0 ; FILE IN : HDFS 
HAS VIEWS : 2434 ; FOLDER IN PROJECT : 1 ; FILE IN PROJECT : 4 ; DOWNLOAD : 0 ;
KEYWORD : [microrarray] , [ breast cancer] , [ NLC-Citral]
19.
HUMAN MESENCHYMAL STEM CELLS-MEDIATED TRANSCRIPTOMIC REGULATION OF LEUKEMIC CELLS IN DELIVERING ANTI-TUMORIGENIC EFFECTS
DESCRIPTION : Treatment of leukemia has become much difficult because of resistance to the existing anticancer therapies. This has thus expedited the search for alternativ therapies, and one of these is the exploitation of mesenchymal stem cells (MSCs) towards control of tumor cells. The present study investigated the effect of human umbilical cord-derived MSCs (UC-MSCs) on the proliferation of leukemic cells and gauged the transcriptomic modulation and the signaling pathways potentially affected by UC-MSCs. The inhibition of growth of leukemic tumor cell lines was assessed by proliferation assays, apoptosis and cell cycle analysis. BV173 and HL-60 cells were further analyzed using microarray gene expression profiling. The microarray results were validated by RT-qPCR and western blot assay for the corresponding expression of genes and proteins. The UC-MSCs attenuated leukemic cell viability and proliferation in a dose-dependent manner without inducing apoptosis. Cell cycle analysis revealed that the growth of tumor cells was arrested at the G0/G1 phase. The microarray results identified that HL-60 and BV173 share 35 differentially expressed genes (DEGs) (same expression direction) in the presence of UC-MSCs. In silico analysis of these selected DEGs indicated a significant influence in the cell cycle and cell cycle-related biological processes and signaling pathways. Among these, the expression of DBF4, MDM2, CCNE2, CDK6, CDKN1A, and CDKN2A was implicated in six different signaling pathways that play a pivotal role in the anti-tumorigenic activity exerted by UC-MSCs. The UC-MSCs perturbate the cell cycle process of leukemic cells via dysregulation of tumor suppressor and oncogene expression.
CONTRIBUTOR : LING KING HWA (11/05/2023 14:43 PM)
FACULTY : FAKULTI PERUBATAN DAN SAINS KESIHATAN
PUBLICATION : 0 ; FILE IN : HDFS 
HAS VIEWS : 541 ; FOLDER IN PROJECT : 1 ; FILE IN PROJECT : 1 ; DOWNLOAD : 0 ;
KEYWORD : [cell cycle; gene expression profiling; leukemia; mesenchymal stem cells]
20.
PROFILING OF SPATIO-TEMPORALLY REGULATED TRANSCRIPTS DURING CEREBRAL CORTICOGENESIS IN THE MOUSE
DESCRIPTION : The cerebral cortex plays an important role in cognitive function and specialized perception in mammals and its development requires highly specific spatio-temporal control of gene expression. The study identified stage- and region-specific markers throughout cerebral corticogenesis at various important stages of cerebral cortex development; embryonic day (E) 15.5, E17.5, postnatal day (P) 1.5 and 4-6 months old. The study involved the analysis of 12 SAGE libraries, which were generated from the mouse cerebral cortex of E15.5 (n=3), E17.5 (n=2), P1.5 (n=1) and 4-6 month old (n=6). N denotes biological replicates.
CONTRIBUTOR : LING KING HWA (11/05/2023 12:42 PM)
FACULTY : FAKULTI PERUBATAN DAN SAINS KESIHATAN
PUBLICATION : 0 ; FILE IN : HDFS 
HAS VIEWS : 2267 ; FOLDER IN PROJECT : 1 ; FILE IN PROJECT : 4 ; DOWNLOAD : 0 ;
KEYWORD : [cerebral cortex] , [ spatio-temporal]
21.
EXPRESSION DATA FROM POSTNATAL MOUSE BRAIN REGIONS OF TS1CJE AND DISOMIC C57BL/6 MICE.
DESCRIPTION : The Ts1Cje mouse model of Down syndrome (DS) has partial triplication of mouse chromosome 16 (MMU16), which is partially homologous to human chromosome 21. The mouse model develops various neuropathological features identified in DS individuals. We analysed the effect of partial triplication of the MMU16 segment on global gene expression in the cerebral cortex, cerebellum and hippocampus of Ts1Cje mice at 4 time-points; postnatal day (P)1, P15, P30 and P84.
CONTRIBUTOR : LING KING HWA (11/05/2023 12:26 PM)
FACULTY : FAKULTI PERUBATAN DAN SAINS KESIHATAN
PUBLICATION : 0 ; FILE IN : HDFS 
HAS VIEWS : 1081 ; FOLDER IN PROJECT : 3 ; FILE IN PROJECT : 3 ; DOWNLOAD : 0 ;
KEYWORD : [postnatal mouse brain] , [ mouse chromosome 16]
22.
INVERSE INFLUENCE OF HLA-DR7, DR12 AND DR13 ON THE PATHOGENESIS OF DER P 1-INDUCED ALLERGIC RHINITIS
DESCRIPTION : Supplementary tables and figures from the yet to be published study entitled \"Inverse influence of HLA-DR7, DR12 and DR13 on the pathogenesis of Der p 1-induced allergic rhinitis\".
CONTRIBUTOR : SETHU THAKACHY SUBHA (11/05/2023 12:15 PM)
FACULTY : FAKULTI PERUBATAN DAN SAINS KESIHATAN
PUBLICATION : 0 ; FILE IN : HDFS 
HAS VIEWS : 591 ; FOLDER IN PROJECT : 1 ; FILE IN PROJECT : 1 ; DOWNLOAD : 0 ;
KEYWORD : [Allergic rhinitis] , [ Human leukocyte antigen] , [ House dust mites] , [ Predisposition] , [ Protection] , [ HLA-DR7] , [ HLA-DR12] , [ HLA-DR13]
23.
IAT DATA
DESCRIPTION : A cross sectional study that was conducted among undergraduate students from June 2020 until October 2020, in a public university in Malaysia. . The IAT questionnaire created by Kimberly Young (1998) was adopted(Young, 1998). This questionnaire has 20 questions with six Likert scale that include the following options from not applicable”, “rarely”, “occasionally”, “frequently”, “often” and “always”. There were four possible methods on calculating the total IAT, namely Method 1, Method 2, Method 3 and Method 4. For Method 1, “not applicable” option was not counted in the total scores of IAT. Only questions with answers from “rarely” until “always” were scored; scored 1 for “rarely” , scored 2 for “occasionally”, scored 3 for “frequently”, scored 4 for “often” and scored 5 for “always”. The total score were summarised and then converted to 100%. For example, if respondent A answered 18 questions, therefore total scores were the summation of 18 questions and then converted to 100%. For Method 2, “not applicable” option was scored as 0 followed with, rarely (scored 1) ,occasionally (scored 2), frequently (scored 3), often (scored 4) and always (scored 5). Total scores were summarisation of 20 questions, with ranging from 0 to 100%(Lu and Yeo, 2015b; Haque et al., 2016; Othman and Lee, 2017; Azhar and Yunus, 2020; Padmavathy KM, Hakim AR, Kalisyah A, Yuhanis Y, Irfan ZA, Luqman R, Arif Z, 2020). For Method 3, six Likert scale was converted to five Likert scale with assuming those respondents who answered “not applicable” option equals to “rarely”. This is assuming that, if the questionnaire does not have “not applicable” option, respondents might choose “rarely” as their answer. Total scores were ranging from 20 to 100(Zainudin, Din and Othman, 2013; Chong Guan et al., 2015; Ching et al., 2017; Rosliza et al., 2018; Mooi et al., 2019; Ying Ying et al., 2021). For Method 4, those questions that were answered with “not applicable” option were treated as missing data, therefore multiple imputation was used. Total scores were ranging from 0 to 100. Total scores from the four different methods were then categorized to four categories variable (IAT-4 categories), including low IA (0-30 scores), mild IA (31-49 scores), moderate IA (50-79 scores) and severe IA (80-100 scores). Further categorization to two categories (IAT-2 categories) with non-IA (low and mild IA: 0-49) and IA (moderate and severe IA: 50-100) was computed.
CONTRIBUTOR : LIM POH YING (11/05/2023 11:06 AM)
FACULTY : FAKULTI PERUBATAN DAN SAINS KESIHATAN
PUBLICATION : 0 ; FILE IN : HDFS 
HAS VIEWS : 327 ; FOLDER IN PROJECT : 1 ; FILE IN PROJECT : 1 ; DOWNLOAD : 0 ;
KEYWORD : [IAT questionnaire] , [ Public university]
24.
MASSIVE MSV000090428-SHEDDING LIGHT ON PIPER’S IDENTITY VIA COMPUTATIONAL MASS SPECTROMETRY
DESCRIPTION : Computational mass spectrometry study involving LC-MS/MS analysis of methanol extracts of lyophilized leaves of Piper rubro-venosum to assess whether the names Piper rubro-venosum and Piper crocatum refer to one species of Piper.
CONTRIBUTOR : KHOZIRAH BINTI SHAARI (11/05/2023 10:55 AM)
FACULTY : INSTITUT BIOSAINS
PUBLICATION : 0 ; FILE IN : HDFS 
HAS VIEWS : 2452 ; FOLDER IN PROJECT : 1 ; FILE IN PROJECT : 0 ; DOWNLOAD : 0 ;
KEYWORD : [Piper cf. fragile] , [ Piper] , [ Piper ornatum] , [ Piper fragile] , [ Piper crocatum] , [ Malaysia] , [ Neolignans]
25.
SCAN FINDINGS OF ISCHAEMIC HEART DISEASE IN ADULTS AGED 30-40 YEARS OLD AS DETECTED AND EVALUATED ON MYOCARDIAL PERFUSION SCINTIGRAPHY
DESCRIPTION : Introduction: Ischaemic heart disease (IHD) is on the rise among adults under 40-years. Radionuclide myocardial perfusion scintigraphy (MPS) can provide imaging information to diagnose, evaluate and risk stratify IHD. Nevertheless, local data are limited on the usage of this technique in identifying IHD among young adult patients. Our objectives were to determine important clinical characteristics of these patients who underwent MPS for IHD detection and highlight their scintigraphy findings. Methodology: A case-series and pictorial review of adults aged 30-40 years old (n=34) who had two-day protocol MPS using 99mTechnetium-tetrofosmin done between January and December 2019. Scan acquisition being performed as per standard departmental protocol. Reversible perfusion defect signified ischaemia whereas irreversible perfusion defect implied infarction. Clinical information and scan findings were compiled and analysed. Results: Average age was 36.59 years. Females were predominant (n=19, 55.9%). Majority had ≥2 cardiovascular risk factors (n=22, 64.7%). Small proportion of patients had morbid obesity (n=3, 8.8%) and intermediate risk for pre-test IHD probability (n=12, 35.3%). Imaging findings of MPS included normal perfusion (n=9, 26.5%), artifact (n=1, 2.9%), ischemia (n=23, 67.6%) and infarction (n=1, 2.9%). Mean ejection fraction on stress MPS was 66%. Patients with ≥2 cardiovascular risks and intermediate probability were significantly associated with abnormal MPS findings (p<0.05). Conclusions: IHD was observed in 70.5% of adults under 40-years who were referred for MPS. Those who had ≥2 cardiovascular risks and intermediate probability were significantly associated with abnormal MPS findings. Attention should be given during scintigraphy images interpretation and reporting of these particular patients
CONTRIBUTOR : SUBAPRIYA A/P SUPPIAH (11/05/2023 10:55 AM)
FACULTY : FAKULTI PERUBATAN DAN SAINS KESIHATAN
PUBLICATION : 0 ; FILE IN : HDFS 
HAS VIEWS : 562 ; FOLDER IN PROJECT : 1 ; FILE IN PROJECT : 1 ; DOWNLOAD : 0 ;
KEYWORD : [Ischaemic heart disease] , [ Radionuclide myocardial perfusion scintigraphy] , [ case series] , [ risk factors]
26.
ALPHA-2-MACROGLOBULIN, AN INFECTION RESISTANT BIOMARKER IN EPINEPHELUS FUSCOGUTTATUS (FORSSKåL, 1775)
DESCRIPTION : Data about an infection resistant biomarker in Epinephelus fuscoguttatus
CONTRIBUTOR : MAHA BINTI ABDULLAH @ MAHA-LAKSWMI-PON (11/05/2023 10:40 AM)
FACULTY : FAKULTI PERUBATAN DAN SAINS KESIHATAN
PUBLICATION : 0 ; FILE IN : HDFS 
HAS VIEWS : 315 ; FOLDER IN PROJECT : 1 ; FILE IN PROJECT : 1 ; DOWNLOAD : 0 ;
KEYWORD : [Alpha-2-macroglobulin]
27.
THE VOLUME OF WASTE GENERATED AND ITS IMPACT ON GHG EMISSIONS, LAND USE, AND HEALTH RISK ASSESSMENT: A STUDY IN MALAYSIA
DESCRIPTION : Waste dumped in landfills was classified as mixed domestic waste or landfilled waste where the available data from 2014 to 2018 only at the time of data collection. Meanwhile, segregated wastes (plastic, paper, metal, aluminium, glass, and e-waste) were collected separately for recycling. As the mandatory waste segregation at source programme started in September 2015, the available data on segregated waste were selected from 2015 to 2018.
CONTRIBUTOR : SHARIFAH NORKHADIJAH BINTI SYED ISMAIL (11/05/2023 10:19 AM)
FACULTY : FAKULTI PERUBATAN DAN SAINS KESIHATAN
PUBLICATION : 0 ; FILE IN : HDFS 
HAS VIEWS : 2044 ; FOLDER IN PROJECT : 1 ; FILE IN PROJECT : 1 ; DOWNLOAD : 0 ;
KEYWORD : [Health] , [ Waste] , [ Land Use]
28.
TUBERCULOSISDATA
DESCRIPTION : time to early TB treatment interruption among newly diagnosed TB patients
CONTRIBUTOR : LIM POH YING (11/05/2023 10:02 AM)
FACULTY : FAKULTI PERUBATAN DAN SAINS KESIHATAN
PUBLICATION : 0 ; FILE IN : HDFS 
HAS VIEWS : 316 ; FOLDER IN PROJECT : 1 ; FILE IN PROJECT : 1 ; DOWNLOAD : 2 ;
KEYWORD : [Tuberculosis (TB)] , [ Tuberculosis (TB) treatment] , [ Hospitalization]
29.
DATASET OF KNOWLEDGE, ATTITUDES AND PRACTICES TOWARDS COVID-19
DESCRIPTION : Dataset of knowledge, attitudes and practices towards COVID-19 among Malaysian
CONTRIBUTOR : HAZWAN BIN MAT DIN (11/05/2023 09:50 AM)
FACULTY : INSTITUT GERONTOLOGI
PUBLICATION : 0 ; FILE IN : HDFS 
HAS VIEWS : 560 ; FOLDER IN PROJECT : 1 ; FILE IN PROJECT : 1 ; DOWNLOAD : 2 ;
KEYWORD : [COVID-19] , [ attitudes] , [ knowledge] , [ practices ]

Organization (Faculty)

Fakulti Perubatan Dan Sains Kesihatan [25]
Fakulti Sains [18]
Fakulti Bioteknologi Dan Sains Biomolekul [6]
Fakulti Sains Komputer Dan Teknologi Maklumat [1]
Fakulti Bahasa Moden Dan Komunikasi [2]
Fakulti Kejuruteraan [2]
Institut Pertanian Tropika Dan Sekuriti Makanan [1]
Institut Gerontologi [2]
Institut Biosains [2]
Fakulti Sains Dan Teknologi Makanan [1]
Pusat Pembangunan Maklumat Dan Komunikasi [1]
Fakulti Ekonomi Dan Pengurusan [2]
Fakulti Perubatan Veterinar [4]
Fakulti Pertanian [8]
Fakulti Ekologi Manusia [2]
Institut Penyelidikan Produk Halal [1]
Institut Penyelidikan Matematik [1]
Fakulti Sains Pertanian Dan Makanan [2]
Institut Perhutanan Tropika Dan Produk Hutan [2]
Kampus Upm Bintulu [1]
Fakulti Perhutanan [6]

Filter By

Subject Area

Agricultural And Biological Sciences [13]
Biochemistry, Genetics And Molecular Biology [12]
Chemical Engineering [1]
Chemistry [11]
Computer Science [3]
Earth And Planetary Sciences [1]
Economics, Econometrics And Finance [1]
Energy [4]
Engineering [3]
Environmental Science [16]
Health Professions [1]
Immunology And Microbiology [4]
Materials Science [14]
Mathematics [1]
Medicine [29]
Pharmacology, Toxicology And Pharmaceutics [2]
Psychology [1]
Social Sciences [7]
Veterinary [5]