DATASETS PHARMACOLOGY

We found 2 data for "PHARMACOLOGY"

LIST DATASET

NO. DATASET TITLE
1.
POTENTIAL ANGIOPREVENTIVE AGENT OF BENZOQUINONOID COMPUND FROM ARDISIA CRISPA ROOT IN VITRO AND IN VIVO
DESCRIPTION : Ardisia crispa (Thunb) A.DC is a local medicinal plant traditionally claimed for its therapeutic use in various inflammatory-related diseases. Its root part has been scientifically validated to be effective in various inflammatory animal models. In this study, we isolated its bioactive compound (AC2) from the hexane fractionated extract of the plant's root (ACRH) and tested its antiangiogenic properties against human umbilical vein endothelial cells (HUVECs) and zebra fish assay, respectively. Our findings exhibited promising antiangiogenic effects of both AC2 and ACRH by suppressing its angiogenic signaling cascades, in vitro as well as significantly inhibited zebrafish embryo intersegmental vessels (ISVs), confirming its antiangiogenic role
CONTRIBUTOR : ROSLIDA BINTI ABD HAMID @ ABDUL RAZAK (29/12/2023 12:18 PM)
FACULTY : FAKULTI PERUBATAN DAN SAINS KESIHATAN
PUBLICATION : 1 ; FILE IN :
HAS VIEWS : 10 ; FOLDER IN PROJECT : 0 ; FILE IN PROJECT : 0 ; DOWNLOAD : 0 ;
KEYWORD : [Ardisia crispa] , [ 2-methoxy-6-undecyl-1] , [4-benzoquinone. HUVECs] , [ cell migration] , [ cell invasion] , [ tube formation] , [ VEGF]
2.
EFFICIENT REMOVAL OF PHARMACEUTICALS FROM WATER USING GRAPHENE NANOPLATELETS AS ADSORBENT
DESCRIPTION : Recently, pharmaceutical pollutants in water emerge as global concern as they give threat to human health and environment. In this study, graphene nanoplatelets (GNPs) were used to efficiently remove antibiotics sulfamethoxazole (SMX) and analgesic acetaminophen (ACM) as pharmaceutical pollutants from water by adsorption process. GNPs; C750, C300, M15, and M5 were characterized by high-resolution transmission electron microscopy, Raman spectroscopy, X-Ray diffraction and Brunauer-Emmett-Teller. The effects of several parameters; viz., solution pH, adsorbent amount, initial concentration and contact time were studied. The parameters were optimized by batch adsorption process and the maximum removal efficiency for both pharmaceuticals were 99%. The adsorption kinetics and isotherms model were employed, and the experimental data were best analysed with pseudo-second kinetic and Langmuir isotherm with maximum adsorption capacity (Qm) of 210.08 mg g-1 for sulfamethoxazole and 56.21 mg g-1 for acetaminophen. Regeneration study were applied using different eluents; 5% ethanol-deionized water 0.005 M NaOH and HCl. GNP C300 were able to remove most of both pollutants from environmental water samples. Molecular docking was used to simulate the adsorption mechanism of GNP C300 towards sulfamethoxazole and acetaminophen with free binding energy of -7.54 kcal mol-1 and -5.29 kcal mol-1 respectively which revealed adsorption occurred spontaneously.
CONTRIBUTOR : HASLINA BINTI AHMAD (11/05/2023 11:52 AM)
FACULTY : FAKULTI SAINS
PUBLICATION : 0 ; FILE IN : HDFS 
HAS VIEWS : 3392 ; FOLDER IN PROJECT : 1 ; FILE IN PROJECT : 1 ; DOWNLOAD : 7 ;
KEYWORD : [pharmaceutical. graphene nanoplatelet] , [ GPN]

Organization (Faculty)

Fakulti Perubatan Dan Sains Kesihatan [25]
Fakulti Sains [18]
Fakulti Bioteknologi Dan Sains Biomolekul [6]
Fakulti Sains Komputer Dan Teknologi Maklumat [1]
Fakulti Bahasa Moden Dan Komunikasi [2]
Fakulti Kejuruteraan [2]
Institut Pertanian Tropika Dan Sekuriti Makanan [1]
Institut Gerontologi [2]
Institut Biosains [2]
Fakulti Sains Dan Teknologi Makanan [1]
Pusat Pembangunan Maklumat Dan Komunikasi [1]
Fakulti Ekonomi Dan Pengurusan [2]
Fakulti Perubatan Veterinar [4]
Fakulti Pertanian [8]
Fakulti Ekologi Manusia [2]
Institut Penyelidikan Produk Halal [1]
Institut Penyelidikan Matematik [1]
Fakulti Sains Pertanian Dan Makanan [2]
Institut Perhutanan Tropika Dan Produk Hutan [2]
Kampus Upm Bintulu [1]
Fakulti Perhutanan [6]

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Subject Area

Agricultural And Biological Sciences [13]
Biochemistry, Genetics And Molecular Biology [12]
Chemical Engineering [1]
Chemistry [11]
Computer Science [3]
Earth And Planetary Sciences [1]
Economics, Econometrics And Finance [1]
Energy [4]
Engineering [3]
Environmental Science [16]
Health Professions [1]
Immunology And Microbiology [4]
Materials Science [14]
Mathematics [1]
Medicine [29]
Pharmacology, Toxicology And Pharmaceutics [2]
Psychology [1]
Social Sciences [7]
Veterinary [5]